Fas/TNFRSF6/CD95 Antibody (ICO-160) Summary
The antibody reacts with the CD95 antigen.
ICO-160 detects CD95 selectively expressed by activated lymphocytes and by a subset of monocytes in peripheral blood and induces apoptosis of activated T and B cells, NK cells an thymocytes. CD95 is a transmembrane glycoprotein of 40 to 50 kD with N-glycosidic-linked polysaccharides. Source: A BALB/c mouse was immunized with activated PBL and the isolated splenocytes were fused with NS1 cells.
Protein A or G purified
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- Flow Cytometry 1:10-1:1000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
ICO-160 can be applied for induction of apoptosis in activated cells.
Mouse. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
0.1 mg/ml PBS
0.05% Sodium Azide
Protein A or G purified
Alternate Names for Fas/TNFRSF6/CD95 Antibody (ICO-160)
- Apo-1 antigen
- apoptosis antigen 1
- Apoptosis-mediating surface antigen FAS
- CD95 antigen
- Fas (TNF receptor superfamily, member 6)
- Fas AMA
- Fas antigen
- FASLG receptor
- TNFRSF6member 6
- tumor necrosis factor receptor superfamily member 6
CD95, also known as FAS or APO1, is a 36 kDa cell surface type I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS PAGE. CD95 is a member of the TNF receptor family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of CD95 Ligand to CD95 or crosslinking of CD95 by anti CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. CD95 belongs to a subgroup of family members that have a death domain (DD) which contains 70 amino acids near the carboxyl terminal region of the molecule. The binding of adaptor molecules to this DD is responsible for transmitting the death signal for apoptosis. Stimulation of CD95 results in aggregation of its DD, leading to the recruitment of FADD and caspase 8 that together with the receptor form the death inducing signaling complex (DISC). CD95/CD95L is involved in the peripheral deletion of activated mature T cells at the end of the immune response and defects in this pathway predispose to autoimmune disorders. CD95 is also involved in killing of targets such as virus infected cells or cancer cells and killing of inflammatory cells at immune privileged sites.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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