Fas Receptor/TNFRSF6/CD95 Antibody (B-R18) [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-Fr
Clone
B-R18
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

Order Details

Fas Receptor/TNFRSF6/CD95 Antibody (B-R18) [Biotin] Summary

Immunogen
Recombinant human CD95 protein
Localization
Cell Surface
Specificity
MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FAS
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Fas Receptor/TNFRSF6/CD95 Antibody (B-R18) [Biotin]

  • ALPS1A
  • APO-1 cell surface antigen
  • Apo-1
  • apoptosis antigen 1
  • apoptosis signaling receptor FAS
  • Apoptosis-mediating surface antigen FAS
  • APT1
  • CD95 antigen
  • CD95
  • Fas (TNF receptor superfamily, member 6)
  • Fas AMA
  • FAS1
  • FASLG receptor
  • FASTM
  • mutant tumor necrosis receptor superfamily member 6
  • TNF receptor superfamily member 6
  • TNFRSF6
  • tumor necrosis factor receptor superfamily member 6
  • tumor necrosis factor receptor superfamily, member 6

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47918AF350
Alexa Fluor 405 NBP2-47918AF405
Alexa Fluor 488 NBP2-47918AF488
Alexa Fluor 532 NBP2-47918AF532
Alexa Fluor 594 NBP2-47918AF594
Alexa Fluor 647 NBP2-47918AF647
Alexa Fluor 700 NBP2-47918AF700
Alexa Fluor 750 NBP2-47918AF750
Allophycocyanin NBP2-47918APC
Allophycocyanin/Cy7 NBP2-47918APCCY7
Biotin NBP2-47918B
DyLight 350 NBP2-47918UV
DyLight 405 NBP2-47918V
DyLight 488 NBP2-47918G
DyLight 550 NBP2-47918R
DyLight 594 NBP2-47918DL594
DyLight 650 NBP2-47918C
DyLight 680 NBP2-47918FR
DyLight 755 NBP2-47918IR
FITC NBP2-47918F
HRP NBP2-47918H
Janelia Fluor 549 NBP2-47918JF549
Janelia Fluor 646 NBP2-47918JF646
PE NBP2-47918PE
PE/Atto594 NBP2-47918PEATT594
PE/Cy5.5 NBP2-47918PECY55
PE/Cy7 NBP2-47918PECY7
PerCP NBP2-47918PCP

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Bioinformatics Tool for Fas/TNFRSF6/CD95 Antibody (NBP2-47918B)

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Bioinformatics

Gene Symbol FAS