FANCD2 Antibody (103)

Images

 
Western Blot: FANCD2 Antibody (103) [NB100-411] - Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with FANCD2 antibody [103] ) diluted at a dilution of 1:1000.
Western Blot: FANCD2 Antibody (103) [NB100-411] - Human FANCD2 protein expression in HeLa whole cell extract (NB800-PC1).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clone
103
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

FANCD2 Antibody (103) Summary

Immunogen
Human FANCD2 fusion protein
Specificity
This is specific for FANCD2.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
FANCD2
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • ELISA
Positive Control
HeLa Lysate (NB800-PC1)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
No Preservative
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for FANCD2 Antibody (103)

  • DKFZp762A223
  • FA4
  • FACD
  • FACDFLJ23826
  • FAD
  • FAD2
  • FA-D2
  • FADFAD2
  • FANCD
  • FANCD2
  • Fanconi anemia group D2 protein
  • Fanconi anemia, complementation group D2
  • Protein FACD2

Background

Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for FANCD2 Antibody (NB100-411) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for FANCD2 Antibody (NB100-411) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional FANCD2 Products

FANCD2 NB100-411

Bioinformatics Tool for FANCD2 Antibody (NB100-411)

Discover related pathways, diseases and genes to FANCD2 Antibody (NB100-411). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for FANCD2 Antibody (NB100-411)

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Pathways for FANCD2 Antibody (NB100-411)

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PTMs for FANCD2 Antibody (NB100-411)

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Research Areas for FANCD2 Antibody (NB100-411)

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Blogs on FANCD2.

FANCD2 and DNA damage repair
Fanconi anemia (FA) is a genetically inherited disorder that yields cytogenetic instability, hypersensitivity to DNA crosslinking compounds and defective DNA repair. A variety of genes have been identified within the FA pathway that are referred t...  Read full blog post.

FANCD2 (Fanconi anemia subunit D2 protein)
Fanconi anemia (FANC) is a rare, autosomal-recessive genetic disorder that is a heterogeneous cancer susceptibility condition that manifests with a wide range of symptoms such as congenital malformations, deteriorating bone marrow failure, DNA-dama...  Read full blog post.

FANCD2: A big component of the DNA repair crew
The genetic disorder known as Fanconi anemia (FANC) is a heterogeneous, autosomal-recessive cancer susceptibility condition characterized by a wide array of symptoms. These include congenital malformations, progressive bone marrow failure, DNA-damage...  Read full blog post.

FANCD2: DNA Repair and Beyond
Fanconi anemia (FANC) is a heterogenous, autosomal-recessive cancer susceptibility genetic disorder that is characterized by a wide array of symptoms, including congenital defects, progressive bone marrow failure due to DNA-damage hypersensitivity, ch...  Read full blog post.

NUP153 & 53BP1: A Novel DNA Repair Pathway
Mediating DNA damage is a crucial process, and one of the most important cellular guards against cancer. In response to DNA damage, sophisticated cellular machinery is recruited to repair the breaks, and if it fails, the cell is committed to death. De...  Read full blog post.

Fanconi Antibodies and Cancer Research
We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)...  Read full blog post.

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Bioinformatics

Gene Symbol FANCD2
Entrez