FAIM2 Antibody

Images

 
Western Blot: FAIM2 Antibody [NBP1-77298] - Western blot analysis of FAIM2 in EL4 cell lysate with FAIM2 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry-Paraffin: FAIM2 Antibody [NBP1-77298] - Mouse brain tissue with FAIM2 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

FAIM2 Antibody Summary

Immunogen
Antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human FAIM2. The immunogen is located within the first 50 amino acids of FAIM2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FAIM2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This antibody can be used for detection of LFG by Western blot at 0.5 - 1 mg/ml.
Control Peptide
FAIM2 Peptide (NBP1-77298PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for FAIM2 Antibody

  • Fas apoptotic inhibitory molecule 2
  • KIAA0950NGP35
  • LFG2
  • LFGLIFEGUARD
  • NMP35neural membrane protein 35
  • Protein lifeguard
  • TMBIM2lifeguard
  • transmembrane BAX inhibitor motif containing 2
  • Transmembrane BAX inhibitor motif-containing protein 2

Background

Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. LFG is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, LFG is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. LFG, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. LFG is widely distributed, but highly expressed in the hippocampus and other neural tissues. LFG was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FAIM2
Uniprot