FADD Antibody

Images

 
Western Blot: FADD Antibody [NBP2-16406] - Sample (30 ug of whole cell lysate) A: A549 12% SDS PAGE gel, diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: FADD Antibody [NBP2-16406] - Confocal immunofluorescence analysis of methanol-fixed HeLa, using FADD antibody (Green) at 1:500 dilution. Alpha-tubulin filaments are labeled with ...read more
Immunohistochemistry-Paraffin: FADD Antibody [NBP2-16406] - Immunohistochemical analysis of paraffin-embedded H1299 xenograft, using antibody at 1:500 dilution.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-16406
    • Availability
      Product Discontinued

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FADD Antibody Summary

Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human FADD. The exact sequence is proprietary.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FADD
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for FADD Antibody

  • FADD
  • Fas (TNFRSF6)-associated via death domain
  • FAS-associated death domain protein
  • FAS-associating death domain-containing protein
  • GIG3
  • Growth-inhibiting gene 3 protein
  • Mediator of receptor induced toxicity
  • mediator of receptor-induced toxicity
  • MGC8528
  • MORT1
  • MORT1Fas-associating protein with death domain
  • protein FADD

Background

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for FADD Antibody (NBP2-16406) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for FADD Antibody (NBP2-16406) (0)

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Secondary Antibodies

 

Isotype Controls

Additional FADD Products

Bioinformatics Tool for FADD Antibody (NBP2-16406)

Discover related pathways, diseases and genes to FADD Antibody (NBP2-16406). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for FADD Antibody (NBP2-16406)

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PTMs for FADD Antibody (NBP2-16406)

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Research Areas for FADD Antibody (NBP2-16406)

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Blogs on FADD.

Apoptosis and Necroptosis Part II: Inhibitors of apoptosis proteins (IAPs); Key regulators of the balance between necroptosis, apoptosis and survival
In the first installment of this two-part blog post titled "Apoptosis and Necroptosis: Important factors to identify both types of programmed cell death", the mechanisms by which cell death occurs and ways to identify these pathways were...  Read full blog post.

FADD - important initiator of death receptor-mediated apoptosis
FAS-associated death domain protein (FADD) is a 23 kDa adaptor protein involved in initiating apoptosis. FADD is best known for its involvement in extrinsic/death receptor-mediated apoptosis, but it is also involved in initiating necroptosis with ...  Read full blog post.

Caspase 9: The Suicidal Cell Whisperer
Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include...  Read full blog post.

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Bioinformatics

Gene Symbol FADD
Entrez
Uniprot