Erythropoietin R Antibody (MM0031-6G7)

Images

 
Western Blot: Erythropoietin R Antibody (MM0031-6G7) [NB110-60997] - Total protein from HeLa (lane 1), A431 (lane 2), MCF7 (lane 3) and PC12 (lane 3) was separated on a 12% gel by SDS-PAGE, transferred to PVDF membrane ...read more
Immunohistochemistry-Paraffin: Erythropoietin R Antibody (MM0031-6G7) [NB110-60997] - Formalin-fixed paraffin-embedded human placenta tissue section was subjected to IHC staining using NB110-60997 (Proteinase K ...read more
Immunohistochemistry-Paraffin: Erythropoietin R Antibody (MM0031-6G7) [NB110-60997] - Buffered formalin fixed Human Tonsil tissue stained with NB110-60997 (Antigen Retieval PK 20mgml in PBS)
Immunohistochemistry-Paraffin: Erythropoietin R Antibody (MM0031-6G7) [NB110-60997] - 4% PFA fixed Human Placenta tissue stained with NB110-60997 (Antigen Retieval PK 20mgml in PBS)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
MM0031-6G7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Erythropoietin R Antibody (MM0031-6G7) Summary

Immunogen
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant EPO receptor (extracellular domain).
Isotype
IgG2
Clonality
Monoclonal
Host
Mouse
Gene
EPOR
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:2000
  • Immunohistochemistry 1:50-1:300
  • Immunohistochemistry-Paraffin 1:50-1:300

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein G purified
Reconstitution Instructions
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for Erythropoietin R Antibody (MM0031-6G7)

  • EpoR
  • EPO-R
  • Erythropoietin R
  • erythropoietin receptor
  • MGC138358

Background

The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol EPOR
Entrez
Uniprot