ERK5/BMK1 Antibody

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Immunoprecipitation: ERK5 Antibody [NBP1-42672] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-ERK5 antibody used for IP at 3 mcg/mg lysate. ERK5 was ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42672
    • Availability
      Product Discontinued

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ERK5/BMK1 Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 475 and 525 of human extracellular-signal-regulated kinase 5 using the numbering given in entry NP_002740.2 (GeneID 5598).
Clonality
Polyclonal
Host
Rabbit
Gene
MAPK7
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 2-5 ug/mg lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ERK5/BMK1 Antibody

  • Big MAP kinase 1
  • BMK1 kinase
  • BMK1
  • BMK-1
  • BMK1EC 2.7.11.24
  • EC 2.7.11
  • ERK5
  • ERK-5
  • ERK5MAPK 7
  • Extracellular signal-regulated kinase 5
  • extracellular-signal-regulated kinase 5
  • MAP kinase 7
  • MAPK7
  • mitogen-activated protein kinase 7
  • PRKM7ERK4

Background

The extracellular signal-regulated kinase 5 (ERK5), also known as MAPK7 or big mitogen-activated protein kinase 1 (BMK1), is a member of the MAP kinase subfamily (1). ERK5 differs considerably from other MAPKs; it contains an unusually long carboxyl-terminal tail which might contribute to the regulation of its activity and/or localization. In response to extracellular signals, ERK5 translocates to the nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors (2). ERK5 also differs from other MAPKs in possessing a potent transcriptional activation domain which mediates protein-protein interactions with the myocyte enhancer factor 2 (MEF2) transcription factors (3). ERK5 is specifically activated by MAPK kinase 5 (MAP2K5/MEK5) and plays an important role in mammary epithelial proliferation, endothelial cell survival and normal embryonic development (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MAPK7
Entrez