ERK1 Antibody

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Immunohistochemistry-Paraffin: ERK1 Antibody [NB110-39044] - Analysis of anti-MAPK3 / ERK1 antibody with human neurons and glia at concentration 7 ug/ml.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB110-39044
    • Availability
      Product Discontinued

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ERK1 Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from internal region of human MAPK3 / ERK1.
Epitope
internal domain of human
Specificity
Human MAPK3 / ERK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MAPK1 (61%).
Predicted Species
Bat (94%), Rabbit (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MAPK3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 7 ug/ml

Reactivity Notes

Gorilla, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Elephant (94%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ERK1 Antibody

  • EC 2.7.11
  • ERK1
  • ERK-1
  • ERK1p44-MAPK
  • ERT2
  • Extracellular signal-regulated kinase 1
  • extracellular signal-related kinase 1
  • HS44KDAP
  • HUMKER1A
  • Insulin-stimulated MAP2 kinase
  • MAP kinase 1
  • MAP kinase 3
  • MAP kinase isoform p44
  • MAPK 1
  • MAPK 3
  • MAPK3
  • MGC20180
  • Microtubule-associated protein 2 kinase
  • Mitogen-activated protein kinase 1
  • mitogen-activated protein kinase 3
  • P44ERK1
  • p44-ERK1
  • p44mapk
  • PRKM3
  • PRKM3EC 2.7.11.24

Background

ERK1, a MAPK-type protein kinase, is a member of the Ras-MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins, and other protein kinases, leading to biological responses such as cell proliferation and differentiation. Inactive ERK1 associates with MAPK/ERK kinases (MEK) 1 and 2 in the cytosol. Upon stimulation, MEK1/2 phosphorylates and activates ERK1 causing dissociation of the MEK/ERK complex. A portion of the activated ERK1 pool forms dimers and translocates to the nucleus to activate nuclear proteins such as ELK-1 and MSK1. Cytosolic ERK 1 acts on a different set of substrates, including MNK1/2 and MAPKAP-K1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional ERK1 Products

Bioinformatics Tool for ERK1 Antibody (NB110-39044)

Discover related pathways, diseases and genes to ERK1 Antibody (NB110-39044). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for ERK1 Antibody (NB110-39044)

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Pathways for ERK1 Antibody (NB110-39044)

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PTMs for ERK1 Antibody (NB110-39044)

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Research Areas for ERK1 Antibody (NB110-39044)

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Blogs on ERK1.

The role of c-Fos in the regulation of the JC virus gene transcription
c-Fos is a member of the AP-1 transcription factor family under the Fos protein family umbrella, alongside Fra-1, Fra-2 and Fos-B.  Also in the AP-1 transcription family are the Jun proteins, c-Jun, Jun-B and Jun-D.  Each member of the AP-1 transcri...  Read full blog post.

The effects of curcumin on IKB Alpha and the NFkB signaling pathway
The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...  Read full blog post.

MAPK3/ERK1 - A signal transduction pathway with roles in development and disease
Mitogen-activated protein kinases (MAPKs) are important signaling proteins needed to transmit and relay extracellular stimuli and to illicit intracellular responses (1). The MAPK family of proteins are serine/threonine kinases that are able to phos...  Read full blog post.

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Bioinformatics

Gene Symbol MAPK3
Entrez