ER beta/NR3A2 Antibody

Images

 
Immunohistochemistry-Paraffin: ER beta/NR3A2 Antibody [NBP1-52471] - Analysis of anti-ER-Beta antibody with human placenta at concentration 3.75 ug/ml.
Immunohistochemistry-Paraffin: ER beta/NR3A2 Antibody [NBP1-52471] - Analysis of anti-ER-Beta antibody with human prostate at concentration 3.75 ug/ml.

Product Details

Summary
Reactivity Hu, Mk, Pm, BtSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

ER beta/NR3A2 Antibody Summary

Immunogen
Synthetic peptide RRQRSADEQLHC from an internal region of human ESR2 / ER-Beta (NP_001035365.1; NP_001035366.1; NP_001428.1).
Specificity
Human ESR2 / ER-Beta. This antibody is expected to recognise all three isoforms (NP_001035365.1; NP_001035366.1; NP_001428.1)
Predicted Species
Bat (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ESR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 3.75 ug/ml

Reactivity Notes

Gorilla, Gibbon. Predicted cross-reactivity based on sequence identity: Mouse (83%), Sheep (83%), Panda (83%), Canine (83%), Bovine (83%), Guinea Pig (83%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ER beta/NR3A2 Antibody

  • ER beta
  • Erb
  • ER-beta
  • ESR2
  • ESR-BETA
  • ESTRB
  • estrogen receptor 2 (ER beta)
  • estrogen receptor beta 4
  • estrogen receptor beta
  • NR3A2
  • NR3A2ESRB
  • Nuclear receptor subfamily 3 group A member 2

Background

The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ESR2
Entrez
Uniprot