epithelial Sodium Channel alpha Antibody

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Order Details


    • Catalog Number
      NBP1-20241
    • Availability
      Product Discontinued

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epithelial Sodium Channel alpha Antibody Summary

Immunogen
A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit alpha (SCNN1A, SCNEA, Alpha-ENaC) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity
SCNN1A.
Clonality
Polyclonal
Host
Sheep
Gene
SCNN1A
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
No Preservative
Concentration
LYOPH
Purity
Unpurified
Reconstitution Instructions
Reconstitute with 0.1 ml sterilized water to desired concentration.

Alternate Names for epithelial Sodium Channel alpha Antibody

  • alpha ENaC-2
  • alpha-ENaC
  • alpha-NaCH
  • amiloride-sensitive epithelial sodium channel alpha subunit
  • amiloride-sensitive sodium channel subunit alpha 2
  • amiloride-sensitive sodium channel subunit alpha
  • BESC2
  • ENaCa
  • ENaCalpha
  • Epithelial Na(+) channel subunit alpha
  • FLJ21883
  • nasal epithelial sodium channel alpha subunit
  • Nonvoltage-gated sodium channel 1 subunit alpha
  • SCNEA
  • SCNN1
  • sodium channel, nonvoltage-gated 1 alpha

Background

FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.; SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note: Apical membrane of epithelial cells.; TISSUE SPECIFICITY: Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.; INDUCTION: By aldosterone.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SCNN1A
Entrez