EPCR Antibody (LMR-42)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42337
    • Availability
      Product Discontinued

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EPCR Antibody (LMR-42) Summary

Immunogen
The antibody reacts with the EPCR antigen.
Specificity
The rat monoclonal antibody LMR-42 detects an outer-surface epitope of a 55 kDa plasma membrane protein overexpressed in several human non-Pgpmultidrug-resistant (MDR) tumor cell lines. Expression cloning revealed that the LMR-42 antigen is identical to the human endothelial cell protein Creceptor (EPCR). Protein C is the zymogen of the key anticoagulant enzyme, activated protein C (APC).
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
PROCR
Purity
Tissue culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
LMR-42 has potential value for the detection of EPCR, which may mediate anti-coagulant and anti-inflammatory functions along vascular endothelia. Whether and how anti-coagulant and anti-inflammatory functions of EPCR facilitate oncogenesis and/or drug-res

Reactivity Notes

Human,Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.1% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for EPCR Antibody (LMR-42)

  • APC receptor
  • CCCA
  • CCD41
  • CCD41centrosome-associated protein
  • CD201 antigen
  • CD201
  • centrocyclin
  • Endothelial cell protein C receptor
  • endothelial protein C receptor
  • EPCR
  • EPCRMGC23024
  • PROCR
  • protein C receptor, endothelial

Background

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PROCR
Entrez