Elk-1 Antibody

Images

 
Western Blot: Elk-1 Antibody [NB100-91749] - Analysis of Elk1 (S411) pAb at 1:500 dilutionLane1:Hela cell lysateLane2:sp2/0 cell lysateLane3:H9C2 cell lysate
Immunohistochemistry-Paraffin: Elk-1 Antibody [NB100-91749] - Analyzes of paraffin-embedded human breast carcinoma tissue at 1:100.
Immunohistochemistry-Paraffin: Elk-1 Antibody [NB100-91749] - Paraffin-embedded human breast carcinoma tissue.

Product Details

Summary
Product Discontinued
View other related Elk-1 Primary Antibodies

Order Details


    • Catalog Number
      NB100-91749
    • Availability
      Product Discontinued

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Elk-1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 380-430 of Human Elk1.
Clonality
Polyclonal
Host
Rabbit
Gene
ELK1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Immunohistochemistry (IHC) analyzes of Elk1 (S411) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Elk-1 Antibody

  • Elk1
  • Elk-1
  • ELK1, member of ETS oncogene family
  • ETS domain-containing protein Elk-1
  • ETS-like gene 1

Background

The transcription factor Elk1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by Elk1. Elk1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 (Ser383) is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Discover related pathways, diseases and genes to Elk-1 Antibody (NB100-91749). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Bioinformatics

Gene Symbol ELK1
Entrez