EGF Antibody

Product Discontinued

EGF Antibody Summary

• Immunogen: Native, from submaxillaries
• Localization: Cell Membrane, single-pass type I membrane protein [precursor] and Secreted [EGF].
• Specificity: Reacts with mouse EGF 100%. Low reactivity with human EGF. Confirmed by Ouchterlony double diffusion.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: EGF
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Radioimmunoassay

Reactivity Notes

Mouse, weakly human Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: Sodium Azide
• Purity: Unpurified

Alternate Names for EGF Antibody

• beta-urogastrone
• EGF
• epidermal growth factor (beta-urogastrone)
• epidermal growth factor
• hEGF
• HOMG4
• pro-epidermal growth factor
• URG
• Urogastrone

Background

Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein. Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EGF
• Entrez:
  • 1950(Human)
  • 13645(Mouse)