Dopamine D1 R/DRD1 Antibody (SG2-D1a) [FITC]

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Product Details

Summary
Reactivity Mu, Rt, Bv(-), Ca(-), Hu(-), Po(-), Rb(-), Sh(-)Species Glossary
Applications ICC/IF, IHC, IHC-Fr
Clone
SG2-D1a
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Dopamine D1 R/DRD1 Antibody (SG2-D1a) [FITC] Summary

Immunogen
Recombinant rat Dopamine Receptor D1 protein near the C-terminus. [Swiss-Prot# P18901]
Localization
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Specificity
This antibody is specific for Dopamine Receptor D1A. There is no cross-reactivity with D1B (D5) receptor.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
DRD1
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
Application Notes
This Dopamine Receptor D1 antibody is useful for Immunocytochemistry/Immunofluorescence, Western Blot and Immunohistochemistry frozen sections. In Western blot multiple bands are seen around 45 and 100 kDa (dimer) in SF9 cell lysates overexpressing D1a and a single band at 90 kDa in striatal tissue lysate. Do NOT boil samples.

Reactivity Notes

Mouse and rat. Does not react with human, dog, pig, sheep, rabbit, or cow.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Dopamine D1 R/DRD1 Antibody (SG2-D1a) [FITC]

  • D(1A) dopamine receptor
  • D1DR
  • DADR
  • Dopamine D1 R
  • Dopamine D1 receptor
  • Dopamine D1R
  • dopamine receptor D1
  • DRD1
  • DRD1A

Background

Dopamine is a unique brain neurotransmitter which is responsible for the regulation of versatile processes such as motor activity, cognition, motivation, emotion, food intake, endocrine secretions etc. and dysfunctions in dopaminergic systems have been linked to drug addiction, schizophrenia, Parkinson's disease, Tourette's syndrome, attention-deficit and hyperactivity disorders as well as hyperprolactinemia. Dopamine Receptor D1 (DRD1), a GPCR protein, is the D1 subtype of dopamine receptors (DR) which represents the most abundant DR in CNS with capability of stimulating adenylyl cyclase and activating cyclic AMP-dependent protein kinases. DRD1 localize to cell membrane/ER membrane as multi-pass membrane protein and its transport from ER to cell surface is regulated by interaction with DNAJC14. DRD1 is highly expressed in the brain tissues, especially in the striatum, the nucleus accumbens, and the olfactory tubercle. DRD1 regulate neuronal growth and development, mediate behavioral responses, and modulate dopamine receptor D2-mediated events.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: ICC/IF, IHC, IHC-Fr

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB110-60017B
DyLight 350 Labeled NB110-60017UV
DyLight 405 Labeled NB110-60017V
DyLight 488 Labeled NB110-60017G
DyLight 550 Labeled NB110-60017R
DyLight 650 Labeled NB110-60017C
DyLight 680 Labeled NB110-60017FR
DyLight 755 Labeled NB110-60017IR
HRP Labeled NB110-60017H

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Bioinformatics

Gene Symbol DRD1
Entrez