DOK2 [p Tyr299] Antibody

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Western Blot: DOK2 [p Tyr299] Antibody [NBP1-51468] - Extracts from 293 serum cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51468
    • Availability
      Product Discontinued

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DOK2 [p Tyr299] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Dok-2 around the phosphorylation site of Tyrosine 299.
Modification
p Tyr299
Specificity
p-Dok-2 (Y299) pAb detects endogenous levels of Dok-2 protein only when phosphorylated at Y299.
Clonality
Polyclonal
Host
Rabbit
Gene
DOK2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
Application Notes
Western blot (WB) analyzes of p-Dok-2 (Y299) pAb in extracts from 293 serum cells.
Theoretical MW
56 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (approx. pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DOK2 [p Tyr299] Antibody

  • docking protein 2
  • docking protein 2, 56kD
  • docking protein 2, 56kDa
  • Dok-2
  • Downstream of tyrosine kinase 2
  • p56(dok-2)
  • p56DOK
  • p56dok-2

Background

Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of -docking- proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, Insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol DOK2