DLL1 Antibody (HMD1-5)

Images

 
Flow Cytometry: DLL1 Antibody (HMD1-5) [NBP2-00275] - Staining of Delta-like 1-transfected CHO cells with 0.25 ug of Armenian Hamster IgG Isotype Control Purified (blue histogram) or 0.25 ug of Anti-Mouse DLL1 ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-00275
    • Availability
      Product Discontinued

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DLL1 Antibody (HMD1-5) Summary

Immunogen
The immunogen for this antibody is DLL1.
Isotype
IgG
Clonality
Monoclonal
Host
Armenian Hamster
Gene
DLL1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This HMD1-5 antibody has been tested by flow cytometric analysis of Delta-like 1-transfected CHO cells. This can be used at less than or equal to 0.5 ug per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. This HMD1-5 antibody has also been reported for use in immunohistology staining of paraffin embedded tissue sections. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous, may contain carrier protein/stabilizer.
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for DLL1 Antibody (HMD1-5)

  • delta (Drosophila)-like 1
  • Delta 1
  • Delta
  • Delta1
  • delta-like 1 (Drosophila)
  • delta-like protein 1
  • DL1
  • DLL1
  • Drosophila Delta homolog 1
  • H-Delta-1

Background

The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Deltalike 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol DLL1
Entrez