Desmoglein-4 Antibody (683135) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: WB
• Clone: 683135
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

Desmoglein-4 Antibody (683135) [Janelia Fluor® 549] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Desmoglein-4
  Glu24-Ala631
  Accession # Q86SJ6
• Specificity: Detects human Desmoglein-4 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human Desmoglein-1, -2, or -3 is observed and approximately 40% cross-reactivity with recombinant mouse Desmoglein-4 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: DSG4
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Desmoglein-4 Antibody (683135) [Janelia Fluor® 549]

• Cad13
• Cadherin family member 13
• CDGF13
• CDHF13
• CDHF13CDH family member 13
• desmoglein 4
• Desmoglein4
• Desmoglein-4
• DSG4
• LAHdesmoglein-4

Background

DSG4, also known as Desmoglein-4, consists of a 113.8 kDa and a 115.5 kDa isoform and is located in the membrane of desmosomes where it moderates cell to cell adhesion. Diseases and disorders such as impetigo, pemphigus foliaceus, skin disease, prostatitis, hypotrichosis, and monilethrix have been researched with this protein. The protein interacts with other proteins including RAB24, MLST8, and PKP3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DSG4