DDB1 Antibody

Images

 
Immunohistochemistry-Paraffin: DDB1 Antibody [NBP1-02782] - Staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
85 mg/ml

Order Details

DDB1 Antibody Summary

Immunogen
Synthetic peptide from human DDB1.
Specificity
Amino acids 198-213 of Human DDB1 (internal) coupled to KLH.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DDB1
Purity
Delipidation and Defibrination
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500 - 1:1000
  • ELISA 1:2000-1:10000
  • Immunohistochemistry 1:500
  • Immunohistochemistry-Paraffin 1:500
  • Immunoprecipitation 1:2000 - 1:10000

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.01% Sodium Azide
Concentration
85 mg/ml
Purity
Delipidation and Defibrination

Alternate Names for DDB1 Antibody

  • damage-specific DNA binding protein 1 (127kD)
  • damage-specific DNA binding protein 1, 127kDa
  • Damage-specific DNA-binding protein 1
  • DDB p127 subunit
  • DDBA
  • DNA damage-binding protein 1
  • DNA damage-binding protein a
  • HBV X-associated protein 1
  • UV-damaged DNA-binding factor
  • UV-damaged DNA-binding protein 1
  • UV-DDB 1
  • UV-DDB1
  • XAP1
  • XAP-1
  • Xeroderma pigmentosum group E-complementing protein
  • XPCE
  • XPE
  • XPE-BF
  • XPE-binding factor

Background

DDB1 is also known as damage-specific DNA binding protein 1, DDB p127 subunit, DDBa, UV-damaged DNA-binding protein 1, UV-DDB 1, Xeroderma pigmentosum group E complementing protein, XPCe, X-associated protein 1 and XAP-1. The DDB1 gene encodes the large subunit (p127) of DNA damage-binding protein, which is a heterodimer, composed of a large and a small subunit (p48 DDB2). This nuclear protein functions in nucleotide-excision repair resulting from UV-damaged DNA by binding to pyrimidine dimers. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). XP-E is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DDB1
Entrez
Uniprot