Cytokeratin 4 Antibody (CK-4)

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Product Details

Summary
Product Discontinued
View other related Cytokeratin 4 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-42573
    • Availability
      Product Discontinued

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Cytokeratin 4 Antibody (CK-4) Summary

Immunogen
Cytokeratin from human esophagus.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KRT4
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2ug/ml
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 2-4ug/ml
  • Immunohistochemistry-Paraffin 2-4ug/ml
  • Immunoprecipitation

Reactivity Notes

Human, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
1.2% Sodium Acetate and 0.2 mg BSA
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified
Reconstitution Instructions
Reconstitute with deionized water.

Alternate Names for Cytokeratin 4 Antibody (CK-4)

  • CK4
  • CK-4
  • CYK4cytokeratin-4
  • Cytokeratin-4
  • FLJ31692
  • K4cytokeratin 4
  • keratin 4
  • keratin, type II cytoskeletal 4
  • Keratin-4
  • Type-II keratin Kb4

Background

Intermediate filaments are protein polymers which, together with actin filaments and microtubules, form the cytoskeleton of cells. A number of human cytokeratins are expressed during the development of stratified epithelia from one-layered polar epithelia and continue to be expressed in several adult epithelial tissues. Expression of the genes encoding these stratification-related cytokeratins starts already in the basal cell layer and does not depend on vertical differentiation and detachment from the basal lamina. Results also show that simple epithelial and stratification-related cytokeratins can be coexpressed in basal cell layers of certain stratified epithelia such as esophagus (1). Mucous keratin CK4 is known to appear in epidermis under certain abnormal conditions. a dose-response study showed that the de novo appearance of K4 can be utilized as a sensitive test for retinoid bioactivity in epidermis in vivo (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KRT4