Cytokeratin 18 Antibody (SP69)

Images

 
Western Blot: Cytokeratin 18 Antibody (SP69) [NBP1-49827] - A431
Immunohistochemistry-Paraffin: Cytokeratin 18 Antibody (SP69) [NBP1-49827] - Human Breast Carcinoma
Immunohistochemistry-Paraffin: Cytokeratin 18 Antibody (SP69) [NBP1-49827] - Keratin 18

Product Details

Summary
Product Discontinued
View other related Cytokeratin 18 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-49827
    • Availability
      Product Discontinued

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Cytokeratin 18 Antibody (SP69) Summary

Immunogen
A synthetic peptide corresponding to C-terminus of human Keratin 18.
Marker
Epithelial Marker
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
KRT18
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This product is useful for Immunohistochemistry Paraffin. Antigen retrieval can be performed using a Citrate process.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
7.0 ml prediluted antibody with 10mM PBS (pH 7.4) and 1.0% BSA
Preservative
0.1% Sodium Azide
Purity
Protein A or G purified

Notes

For a positive control use Breast carcinoma.

Alternate Names for Cytokeratin 18 Antibody (SP69)

  • Cell proliferation-inducing gene 46 protein
  • cell proliferation-inducing protein 46
  • CK-18
  • CYK18
  • Cytokeratin 18
  • cytokeratin-18
  • K18
  • Keratin 18
  • keratin, type I cytoskeletal 18
  • keratin-18
  • KRT18

Background

Cytokeratin 18 (CK-18), a normal constituent of the hepatocyte cytoskeleton) is a standard tumor marker. CK-18 is elevated in patients with non-malignant liver diseases, particularly in those with prominent cytolysis (1). CK-18 and the homologous mouse Endo B are type I IF protein subunits whose expression is restricted in adults to a variety of simple epithelial tissues. Keratin 8 and 18 (CK8/18) are the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine. Transgenic mice that express mutant keratin 18 develop chronic hepatitis, and have an increased susceptibility to drug-induced hepatotoxicity (2). Studies shows that high CK18 expression in tumor cells is associated with reduced invasiveness in vitro and lack of tumorigenicity in nude mice. It has been shown that high K18 expression correlated with a good prognosis and that reducing K18 expression increased the aggressiveness of established breast cancer cell lines (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics Tool for Cytokeratin 18 Antibody (NBP1-49827)

Discover related pathways, diseases and genes to Cytokeratin 18 Antibody (NBP1-49827). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for Cytokeratin 18 Antibody (NBP1-49827)

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Blogs on Cytokeratin 18.

Cytokeratin 18 - A Intermediate Filament Cyotskeletal Component
Keratins, also called cytokeratins, are a family of filamentous structural proteins that form the intermediate filaments within epithelial cells. Keratins are differentially expressed depending on both the epithelial cell origin and degree of differen...  Read full blog post.

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Bioinformatics

Gene Symbol KRT18
Entrez