Cytokeratin 14/16/17 Antibody

Images

 
Western Blot: Cytokeratin 14/16/17 Antibody [NB100-91840] - Analysis of Cytokeratin 14/16/17 antibody in extracts from NIH/3T3 cells.
Immunohistochemistry-Paraffin: Cytokeratin 14/16/17 Antibody [NB100-91840] - Analyzes of paraffin-embedded human breast carcinoma tissue.
Western Blot: Cytokeratin 14/16/17 Antibody [NB100-91840] - Analysis of Cytokeratin 14/16/17 pAb at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:Mouse brain tissue lysate Lane3:Rat brain tissue lysate

Product Details

Summary
Product Discontinued
View other related Cytokeratin 14/16/17 Primary Antibodies

Order Details


    • Catalog Number
      NB100-91840
    • Availability
      Product Discontinued

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Cytokeratin 14/16/17 Antibody Summary

Immunogen
Synthetic peptide, corresponding to the N-terminus of Human Cytokeratin 14
Specificity
Detects endogenous expression of Cytokeratin 14 (Gene ID: 3861, UniProt: P02533), Cytokeratin 16 (Gene ID: 3868, UniProt: P08779), and Cytokeratin 17 (Gene ID: 3872, UniProt: Q04695).
Clonality
Polyclonal
Host
Rabbit
Gene
KRT14
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Theoretical MW
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NB100-91840 in the following applications:

  • IHC
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cytokeratin 14/16/17 Antibody

  • CK14
  • CK-14
  • cytokeratin 14
  • cytokeratin-14
  • EBS3
  • EBS4
  • K14
  • keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)
  • keratin 14
  • keratin, type I cytoskeletal 14
  • keratin-14
  • NFJ

Background

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and in addition they aid in the characterization of malignant tumors. In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Cytokeratin 14/16/17 Antibody (NB100-91840)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC.


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Video Protocols

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ICC/IF Video Protocol

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Diseases for Cytokeratin 14/16/17 Antibody (NB100-91840)

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Bioinformatics

Gene Symbol KRT14