Cytochrome P450 2A6 Antibody (9G3)

Images

 
Western Blot: Cytochrome P450 2A6 Antibody (9G3) [NBP2-01636] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Cytochrome P450 2A6 (Right lane) cDNA for 48 hrs and lysed. ...read more
Immunohistochemistry-Paraffin: Cytochrome P450 2A6 Antibody (9G3) [NBP2-01636] Staining of paraffin-embedded Human lymphoma tissue using anti-Cytochrome P450 2A6 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Cytochrome P450 2A6 Antibody (9G3) [NBP2-01636] - Staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-Cytochrome P450 2A6 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Cytochrome P450 2A6 Antibody (9G3) [NBP2-01636] - Staining of paraffin-embedded Human liver tissue using anti-Cytochrome P450 2A6 mouse monoclonal antibody.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-01636
    • Availability
      Product Discontinued

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Cytochrome P450 2A6 Antibody (9G3) Summary

Immunogen
Full length human recombinant protein of human CYP2A6(NP_000753) produced in HEK293T cell.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CYP2A6
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000-2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:150

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Cytochrome P450 2A6 Antibody (9G3)

  • Coumarin 7-hydroxylase
  • CPA6
  • CYP2A3P450C2A
  • CYP2AEC 1.14.14.1
  • CYPIIA6
  • cytochrome P450 2A6
  • Cytochrome P450 IIA3
  • Cytochrome P450(I)
  • cytochrome P450, family 2, subfamily A, polypeptide 6
  • cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6
  • flavoprotein-linked monooxygenase
  • P450PB
  • xenobiotic monooxygenase

Background

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CYP2A6
Entrez