Cytochrome P450 1A2 Antibody

Western Blot: Cytochrome P450 1A2 Antibody [H00001544-D01P] - Analysis of CYP1A2 expression in transfected 293T cell line by CYP1A2 polyclonal antibody.Lane 1: CYP1A2 transfected lysate(58.50 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

Cytochrome P450 1A2 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: CYP1A2 (AAH67427.1, 1 a.a. - 516 a.a.) full-length human protein. MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIDSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
• Specificity: Reacts with cytochrome P450, family 1, subfamily A, polypeptide 2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CYP1A2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is reactive against transfected lysate in WB and as a detection antibody in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Cytochrome P450 1A2 Antibody

• aryl hydrocarbon hydroxylase
• CP12
• CYP1A2
• CYPIA2
• Cytochrome P(3)450
• Cytochrome P450 1A2
• Cytochrome P450 4
• cytochrome P450, family 1, subfamily A, polypeptide 2
• cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
• Cytochrome P450-P3
• dioxin-inducible P3-450
• EC 1.14.14.1
• flavoprotein-linked monooxygenase
• microsomal monooxygenase
• P3-450
• P450 form 4
• P450(PA)
• xenobiotic monooxygenase

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CYP1A2
• Entrez:
  • 1544(Human)
• Uniprot:
  • AAH67427.1(Human)