CYP46A1 Antibody

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Product Details

Summary
Product Discontinued
View other related CYP46A1 Primary Antibodies

Order Details


    • Catalog Number
      NB100-63133
    • Availability
      Product Discontinued

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CYP46A1 Antibody Summary

Immunogen
Synthetic peptide corresponding to amino acid sequence 254-270 of human cholesterol 24-hydroxylase protein.
Specificity
NB100-63133 recognizes cholesterol 24-hydroxylase (CYP46A1), a 58 kDa member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system. P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CYP46A1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
Positive Control
CYP46A1 Lysate (NBL1-09694)

Reactivity Notes

Human. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.09% Sodium Azide
Purity
Unpurified

Alternate Names for CYP46A1 Antibody

  • CH24H
  • cholesterol 24-hydroxylase
  • CYP46CP46
  • Cytochrome P450 46A1
  • cytochrome P450, family 46, subfamily A, polypeptide 1
  • cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
  • EC 1.14.13.98

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CYP46A1
Entrez
Uniprot