CXCR6 Antibody

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Western Blot: CXCR6 Antibody [NBP1-46940] - Western blot analysis of Bonzo in SW1353 total cells lysate with anti-Bonzo (CT) at 1:1000 dilution.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-46940
    • Availability
      Product Discontinued

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CXCR6 Antibody Summary

Immunogen
A synthetic peptide corresponding to amino acids 319 to 338 of human origin (1, 2).
Clonality
Polyclonal
Host
Rabbit
Gene
CXCR6
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000

Reactivity Notes

human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
IgG purified

Alternate Names for CXCR6 Antibody

  • Bonzo
  • BONZOG-protein coupled receptor bonzo
  • CD186 antigen
  • CD186
  • CDw186
  • chemokine (C-X-C motif) receptor 6
  • C-X-C chemokine receptor type 6
  • CXCR6
  • CXC-R6
  • CXCR-6
  • G protein-coupled receptor
  • STRL33
  • STRL33G-protein coupled receptor STRL33
  • TYMSTRCD186

Background

Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) require coreceptors to enter and infect target cells. They are dependent upon an interaction between the viral envelope glycoprotein with T-cell antigen T4 (CD4) and a G protein coupled receptor (GPCR). HIV-1 infection relies upon interaction with a chemokine receptor, usually chemokine (C-C) receptor 5 (CCR5). During progression of the infection, the virus tends to rely upon chemokine (C-X-C) receptor 4 (CXCR4). SIV also utilizes CCR5 in the early stages of infection, but during progression it tends to rely on two orphan GPCR's named chemokine (C-X-C) receptor 6 (Bonzo) and G protein coupled receptor 15 (BOB/GRP15). Bonzo mRNA expression has been localized to lymphoid tissues and activated peripheral blood lymphocytes. Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require co-receptors, in addition to CD4, to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV co-receptors. An orphan G protein coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV co-receptor (1-4). Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CXCR6
Entrez