CXCR2/IL-8 RB Antibody (5E8-C7-F10) [PE]

Images

 
Flow Cytometry: CXCR2/IL-8 RB Antibody (5E8-C7-F10) [PE] [NBP2-00220] - Staining of normal human peripheral blood cells with Anti-Human CD4 APC (left) or Anti-Human CD56 (NCAM) APC (right) and Anti-Human CD182 (CXCR2) ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
5E8-C7-F10
Clonality
Monoclonal
Host
Mouse
Conjugate
PE

CXCR2/IL-8 RB Antibody (5E8-C7-F10) [PE] Summary

Immunogen
The immunogen for this antibody was CD182.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CXCR2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified

Alternate Names for CXCR2/IL-8 RB Antibody (5E8-C7-F10) [PE]

  • beta
  • CD182 antigen
  • CD182
  • CDw128b
  • chemokine (C-X-C motif) receptor 2
  • chemokine (CXC) receptor 2
  • C-X-C chemokine receptor type 2
  • CXCR2 gene for IL8 receptor type B
  • CXCR2
  • CXC-R2
  • CXCR-2
  • GRO/MGSA receptor
  • High affinity interleukin-8 receptor B
  • IL-8 receptor type 2
  • IL-8R B
  • IL8R2
  • IL8RA
  • IL8RB
  • IL-8RB
  • interleukin 8 receptor B
  • interleukin 8 receptor type 2
  • interleukin-8 receptor type B

Background

The 5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8R beta). CD182 is a 67-70 kDa member of the seventransmembrane spanning G-protein coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8R alpha) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO alpha, -beta and -gamma, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CXCR2
Entrez