CXCR1/IL-8 RA Antibody (42705) [Fluorescein]

Images

 
Human peripheral blood granulocytes were stained with Mouse Anti-Human CXCR1/IL‑8 RA Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB330F, filled histogram) or isotype control antibody (Catalog # IC003F, ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
42705
Clonality
Monoclonal
Host
Mouse
Conjugate
Fluorescein

CXCR1/IL-8 RA Antibody (42705) [Fluorescein] Summary

Additional Information
Clone 42705 was used by HLDA to establish CD designation
Immunogen
NS0 mouse myeloma cell line transfected with human CXCR1/IL-8 RA
Met1-Leu350
Accession # AAA59159
Specificity
Detects human CXCR1/IL-8 RA transfectants but not the parental cell line. It does not cross-react with human CXCR2.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CXCR1
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB330F in the following applications:

  • 6 publications

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR1/IL-8 RA Antibody (42705) [Fluorescein]

  • CD128
  • CD181 antigen
  • CD181
  • CDw128aC-C
  • chemokine (C-X-C motif) receptor 1
  • CKR-1
  • CMKAR1
  • C-X-C chemokine receptor type 1
  • CXCR1
  • CXC-R1
  • CXCR-1
  • High affinity interleukin-8 receptor A
  • IL-8 receptor type 1
  • IL-8R A
  • IL8R1
  • IL8RA
  • IL-8RA
  • IL8RAC-C-CKR-1
  • IL8RBA
  • interleukin 8 receptor, alpha
  • interleukin-8 receptor type 1
  • interleukin-8 receptor type A

Background

The human C-X-C chemokine IL-8 is a potent neutrophil chemotactic and activating factor. Two distinct G protein-linked cell surface receptors, known as IL-8 RA (type I or CXCR1) and IL-8 RB (type II or CXCR2), can interact with the IL-8 molecule. These two receptors share 77% amino acid homology. CXCR1 expression has been documented on neutrophils, monocytes, and a small population of T cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCR1/IL-8 RA Antibody (FAB330F)(7)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow.


Filter By Application
Flow
(6)
All Applications
Filter By Species
Human
(6)
All Species
Showing Publications 1 - 7 of 7.
Publications using FAB330F Applications Species
Zaidoon Al-Jaderi Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity Front Immunol, 2016;7(0):437. 2016 [PMID: 27807435] (Flow,, Human) Flow Human
Hazeldine J, Harris P, Chapple I, Grant M, Greenwood H, Livesey A, Sapey E, Lord J Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell, 2014;13(4):690-8. 2014 [PMID: 24779584] (Flow,, Human) Flow Human
Morandi, Fabio, Di Carlo, Emma, Ferrone, Soldano, Petretto, Andrea, Pistoia, Vito, Airoldi, Irma IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol, 2014;192(6):2634-42. 2014 [PMID: 24554774]
Liu L, Xie F, Chang K, Li M, Meng Y, Wang X, Li H, Li D, Yu J Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8. Int J Clin Exp Pathol, 0;7(2):575-83. 0 [PMID: 24551277] (Flow,, Human) Flow Human
Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA Identification of human NK17/NK1 cells. PLoS ONE, 2011;6(10):e26780. 2011 [PMID: 22039549] (Flow,, Human) Flow Human
Eikawa S, Ohue Y, Kitaoka K Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. J. Immunol., 2010;185(11):6734-40. 2010 [PMID: 21048114] (Flow,, Human) Flow Human
Maxwell PJ, Gallagher R, Seaton A, Wilson C, Scullin P, Pettigrew J, Stratford IJ, Williams KJ, Johnston PG, Waugh DJ HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells. Oncogene, 2007;26(52):7333-45. 2007 [PMID: 17533374] (Flow,, Human) Flow Human

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CXCR1
Uniprot