CXCL4/PF4 Native Protein Summary
A non-recombinant protein corresponding to 70 amino acids of Human CXCL4/PF4
Source: Human platelets
Amino Acid Sequence: The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.
|Details of Functionality
Binding of HIT-antibodies.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
From PBS buffer, pH 7.4.
Reconstitute with sterilized deionized water to a final concentration greater than or equal to 0.1 mg/ml.
After reconstituted, dilute further with other aqueous solutions.
Alternate Names for CXCL4/PF4 Native Protein
- chemokine (C-X-C motif) ligand 4
- C-X-C motif chemokine 4
- platelet factor 4
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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