CXCL16 Recombinant Protein Summary
A recombinant protein corresponding to 88 amino acids of Mouse CXCL16
Source: E. coli
Amino Acid Sequence: NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Filtered solution containing 20 mM sodium phosphate buffer, pH 7.4 and 50 mM NaCl.
Reconstitute with sterilized deionized water to a final concentration greater than or equal to 0.1 mg/ml.
After reconstituted, dilute further with other aqueous solutions.
Alternate Names for CXCL16 Recombinant Protein
- chemokine (C-X-C motif) ligand 16
- CXC chemokine ligand 16
- Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
- Small-inducible cytokine B16
- SRPSOXC-X-C motif chemokine 16
- SR-PSOXTransmembrane chemokine CXCL16
Mouse CXCL16 is a nonELR motif including CXC chemokine with a transmembrane domain. CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in atherogenesis. Mouse CXCL16 is generated by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membrane bound and soluble forms. CXCL16 is expressed in the spleen, lymph nodes, Peyer patches non-lymphoid tissues (e.g. lung, kidney, small intestine, thymus). It is weakly expressed in heart and liver and not expressed in brain and purified B- and T-cells. CXCL16 deficiency is linked to breast cancer progression and is involved in immunological liver injury (by regulating T lymphocyte infiltration). CXCL16 has a distinctive role in the maintenance of cardiac allograft tolerance mediated by natural killer T cells, and in the production of IFN-gamma by NKT cells and promotion of Th1-inclined immune responses mediated by NKT cells. CXCL16 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 9.9kDa. The CXCL16 is purified by proprietary chromatographic techniques.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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