Recombinant Mouse CXCL16 Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-99338
    • Availability
      Product Discontinued

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Recombinant Mouse CXCL16 Protein Summary

Description
A recombinant protein corresponding to 88 amino acids of Mouse CXCL16

Amino Acid Sequence: NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP
Preparation
Method
>97% SDS-PAGE
Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
CXCL16
Purity
>95%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
9.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Buffer
Lyophilized from a filtered solution containing 20 mM sodium phosphate buffer, pH 7.4 and 50 mM NaCl.
Concentration
Lyoph
Purity
>95%, by SDS-PAGE
Reconstitution Instructions
Reconstitute in sterile ddH2O to a concentration> 100 ug/ml. This solution can then be diluted into other aqueous buffers.

Alternate Names for Recombinant Mouse CXCL16 Protein

  • chemokine (C-X-C motif) ligand 16
  • CXC chemokine ligand 16
  • CXCL16
  • CXCLG16
  • Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
  • SCYB16
  • Small-inducible cytokine B16
  • SRPSOXC-X-C motif chemokine 16
  • SR-PSOXTransmembrane chemokine CXCL16

Background

Mouse CXCL16 is a nonELR motif including CXC chemokine with a transmembrane domain. CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in atherogenesis. Mouse CXCL16 is generated by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membrane bound and soluble forms. CXCL16 is expressed in the spleen, lymph nodes, Peyer patches non-lymphoid tissues (e.g. lung, kidney, small intestine, thymus). It is weakly expressed in heart and liver and not expressed in brain and purified B- and T-cells. CXCL16 deficiency is linked to breast cancer progression and is involved in immunological liver injury (by regulating T lymphocyte infiltration). CXCL16 has a distinctive role in the maintenance of cardiac allograft tolerance mediated by natural killer T cells, and in the production of IFN-gamma by NKT cells and promotion of Th1-inclined immune responses mediated by NKT cells. CXCL16 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 9.9kDa. The CXCL16 is purified by proprietary chromatographic techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol CXCL16
Entrez