Recombinant Human CXCL10/IP-10/CRG-2 Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-43156
    • Availability
      Product Discontinued

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Recombinant Human CXCL10/IP-10/CRG-2 Protein Summary

Description
A partial protein corresponding to CXCL10.
Preparation
Method
E. coli.
Details of Functionality
This recombinant human IP-10 has been tested in bioassays for chemoattractant activity with maximal activity observed between 10-100 ng/ml.
Protein/Peptide Type
Partial Recombinant Protein
Gene
CXCL10
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Applications/Dilutions

Application Notes
This recombinant human CXCL10/INP10 has been tested in bioassays for chemoattractant activity on human T lymphocytes previously cultured with IL-2 with maximal activity observed between 10-100 ng/ml.

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline, pH 7.2, 150 mM NaCl, with 1.0% BSA. 0.22 um filtered.
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 97%, as determined by SDS-PAGE

Alternate Names for Recombinant Human CXCL10/IP-10/CRG-2 Protein

  • C7
  • chemokine (C-X-C motif) ligand 10
  • CRG2
  • CRG-2
  • CXCL10
  • gIP-10
  • IFI10
  • INP10
  • IP-10
  • mob-1
  • SCYB10

Background

IP-10, or Interferon Gamma Inducible Protein 10, is a CXC chemokine also known as CXCL10. IP-10 is induced in monocytes, fibroblasts, and endothelial cells by IFNgamma. It is also induced by LPS, IL-1beta, TNF-alpha, IL-12, and viral infection. IP-10 is a chemoattractant for CXCR3+ T cells, which plays an important role in Th1-type inflammatory diseases, as well as several endocrine-related autoimmune diseases such as Hashimotos thyroiditis. Recombinant human IP-10 produced in E.Coli is a single, non-glycosylated polypeptide containing 77 amino acids and with a molecular mass of 8.5 kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol CXCL10
Entrez