Alternate Names for CXCL10/IP-10/CRG-2 Antibody (6D4)
chemokine (C-X-C motif) ligand 10
Interferon-gamma-inducible 10 kD protein (IP-10), is a CXC chemokine with chemoattractant properties for CD4-positive T cells and inhibits early normal and leukemic hemopoietic progenitor proliferation. IP-10 is produced by a wide variety of cell types ranging from neutrophils and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV encephalitis, cutaneous T cell lymphoma, chronic hepatitis and acute anterior uveitis. Various observations strongly suggest a role for the CXC chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Hamamdzic D, Phillips-Dorsett T, Altman-Hamamdzic S et al. Reovirus triggers cell type-specific proinflammatory responses dependent on the autocrine action of IFN-beta Am J Physiol Lung Cell Mol Physiol
Giustizieri ML, Albanesi C, Scarponi C et al. Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo Am J Pathol
Curbishley SM, Eksteen B, Gladue RP et al. CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow Am J Pathol
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