Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [DyLight 405]

Images

 
There are currently no images for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, Flow, IHC-Fr, IHC-P
Clone
HECA-452
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 405

Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [DyLight 405] Summary

Immunogen
Human tonsil stroma
Specificity
Cutaneous Lymphocyte Antigen
Isotype
IgM Kappa
Clonality
Monoclonal
Host
Rat
Gene
SELPLG
Purity
IgM purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
The HECA-452 antibody cross-reacts with mouse skin homing lymphocytes. Purity is > 85%. IHC use reported in literature (see Duijvestijn AM, et al).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
IgM purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [DyLight 405]

  • CD162 antigen
  • CD162
  • CLA
  • Cutaneous Lymphocyte-Associated Associated Antigen
  • P-selectin glycoprotein ligand 1
  • PSGL1
  • PSGL-1
  • Selectin P Ligand

Background

Cutaneous Lymphocyte Antigen (CLA) is a single-pass type I membrane homodimer protein (140kDa) that collects in normal and inflamed skin. It is expressed on T lymphocytes, subsets of peripheral blood memory T cells, Natural Killer cells, memory B cells and dendritic cells, as well as on monocytes and granulocytes. CLA is a carbohydrate epitope of sialic acid and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1). CLA is a subset ligand for E-selectin, P-selectin, and L-selectin. It plays a role in leukocyte tethering and rolling over vascular surfaces during inflammation. Treatment of activated HUVEC cells with HECA-452 antibody inhibits lymphocyte adhesion. The HECA-452 antibody is cross-reactive with mouse CLA and is appropriate for staining formalin-fixed paraffin embedded tissue sections.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-34260
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC-Fr, IHC-P, IP
NB120-19481
Species: Hu, Mu, Rt, Po, Bv, Ca, Ch, Ha
Applications: WB, IHC, IHC-P
NB200-610
Species: Hu, Ca, GP
Applications: Flow, ICC/IF, IHC, IHC-Fr, IP
NBP2-14921
Species: Hu
Applications: WB, IHC, IHC-P
NB100-2564
Species: Hu
Applications: WB
NBP2-01743
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
NBP1-19371
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
NB100-524
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, Flow-IC
NBP1-84550
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
NB110-89474
Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
NB100-1831
Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
NB100-78039V
Species: Hu, Mu
Applications: WB, ELISA, Flow, IHC-Fr, IHC-P

Publications for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V) (0)

There are no publications for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V) (0)

There are no reviews for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-78039APC
DyLight 350 Labeled NB100-78039UV
DyLight 488 Labeled NB100-78039G
DyLight 680 Labeled NB100-78039FR
DyLight 755 Labeled NB100-78039IR
PE Labeled NB100-78039PE
PerCP Labeled NB100-78039PCP

Additional Cutaneous Lymphocyte Antigen (CLA) Products

Cutaneous Lymphocyte Antigen (CLA) NB100-78039V

Related Products by Gene

Bioinformatics Tool for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V)

Discover related pathways, diseases and genes to Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V)

Discover more about diseases related to Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V).
 

Pathways for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V)

View related products by pathway.

PTMs for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V)

Learn more about PTMs related to Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V).
 

Research Areas for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039V)

Find related products by research area.

Blogs on Cutaneous Lymphocyte Antigen (CLA).

CLA - guiding T-cells to sites of inflammation
T-cells infiltrating sites of inflammation of the skin typically express the cutaneous lymphocyte-associate antigen (CLA). This antigen is defined by the binding of the monoclonal CLA antibody HECA-452. The CLA antigen is a fucose-containing oligo...  Read full blog post.

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [DyLight 405] and receive a gift card or discount.

Bioinformatics

Gene Symbol SELPLG

Customers Who Bought This Also Bought

CD11b Antibody
NB110-89474
CD11b Antibody
NB110-89474
CD11b Antibody
NB110-89474