Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [PerCP]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow, IHC, IHC-Fr, IHC-P
Clone
HECA-452
Clonality
Monoclonal
Host
Rat
Conjugate
PerCP

Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [PerCP] Summary

Immunogen
Human tonsil stroma
Specificity
Cutaneous Lymphocyte Antigen
Isotype
IgM Kappa
Clonality
Monoclonal
Host
Rat
Gene
SELPLG
Purity
IgM purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
The HECA-452 antibody cross-reacts with mouse skin homing lymphocytes. Purity is > 85%. IHC use reported in literature (see Duijvestijn AM, et al).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
IgM purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [PerCP]

  • CD162 antigen
  • CD162
  • CLA
  • Cutaneous Lymphocyte-Associated Associated Antigen
  • P-selectin glycoprotein ligand 1
  • PSGL1
  • PSGL-1
  • Selectin P Ligand

Background

Cutaneous Lymphocyte Antigen (CLA) is a single-pass type I membrane homodimer protein (140kDa) that collects in normal and inflamed skin. It is expressed on T lymphocytes, subsets of peripheral blood memory T cells, Natural Killer cells, memory B cells and dendritic cells, as well as on monocytes and granulocytes. CLA is a carbohydrate epitope of sialic acid and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1). CLA is a subset ligand for E-selectin, P-selectin, and L-selectin. It plays a role in leukocyte tethering and rolling over vascular surfaces during inflammation. Treatment of activated HUVEC cells with HECA-452 antibody inhibits lymphocyte adhesion. The HECA-452 antibody is cross-reactive with mouse CLA and is appropriate for staining formalin-fixed paraffin embedded tissue sections.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-78039APC
DyLight 350 Labeled NB100-78039UV
DyLight 405 Labeled NB100-78039V
DyLight 488 Labeled NB100-78039G
DyLight 680 Labeled NB100-78039FR
DyLight 755 Labeled NB100-78039IR
PE Labeled NB100-78039PE

Additional Cutaneous Lymphocyte Antigen (CLA) Products

Cutaneous Lymphocyte Antigen (CLA) NB100-78039PCP

Bioinformatics Tool for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039PCP)

Discover related pathways, diseases and genes to Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039PCP). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039PCP)

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Pathways for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039PCP)

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PTMs for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039PCP)

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Research Areas for Cutaneous Lymphocyte Antigen (CLA) Antibody (NB100-78039PCP)

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Blogs on Cutaneous Lymphocyte Antigen (CLA).

CLA - guiding T-cells to sites of inflammation
T-cells infiltrating sites of inflammation of the skin typically express the cutaneous lymphocyte-associate antigen (CLA). This antigen is defined by the binding of the monoclonal CLA antibody HECA-452. The CLA antigen is a fucose-containing oligo...  Read full blog post.

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Bioinformatics

Gene Symbol SELPLG