CTP synthase Antibody

Images

 
Western Blot: CTP synthase Antibody [NBP1-51201] - Analysis of CTP (K109) pAb in extracts from HuvEc cells
Immunohistochemistry-Paraffin: CTP synthase Antibody [NBP1-51201] - Human liver carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51201
    • Availability
      Product Discontinued

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CTP synthase Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 80-130 of Human CTPS.
Specificity
CTPS (K109) pAb detects endogenous levels of CTPS protein.
Clonality
Polyclonal
Host
Rabbit
Gene
CTPS1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of CTPS (K109) pAb in extracts from HuvEc cellsImmunohistochemistry (IHC) analyzes of CTPS (K109 pAb in paraffin-embedded human liver carcinoma tissue.
Theoretical MW
67 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CTP synthase Antibody

  • CTP synthase 1
  • CTP synthase
  • CTP synthetase 1
  • cytidine 5-prime triphosphate synthetase
  • cytidine 5'-triphosphate synthetase
  • EC 6.3.4.2
  • UTP--ammonia ligase 1

Background

CTPS (cytidine-5-prime-triphosphate synthase) is a 591 amino acid protein that contains one glutamine amidotransferase type-1 domain and is involved in pyrimidine metabolism. CTPS catalyzes the ATP-dependent conversion of UTP to CTP, a rate-limiting reaction that requires either ammonia or L-glutamine as a nitrogen source. Via its catalytic activity, CTPS plays an important role in the synthesis of nucleic acids and is crucial for proper cell growth and development. The function of CTPS is regulated by a variety of mechanisms, including phosphorylation by protein kinase C (PKC), an event that can either stimulate or inhibit CTPS activity. The gene encoding CTPS is located in a region on chromosome 1 that is often associated with the progression of several tumor types, suggesting a possible role for CTPS in tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CTPS1