CSE1L/CAS/Exportin-2 Antibody

Images

 
Western Blot: CSE1L/CAS/Exportin-2 Antibody [NB100-91723] - analysis of CSE1L/CAS/Exportin-2pAb at 1:500 dilutionLane1:Hela cell lysateLane2:sp2/0 cell lysateLane3:PC12 cell lysate treated with UV
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NB100-91723] - Paraffin-embedded human brain tissue.
Western Blot: CSE1L/CAS/Exportin-2 Antibody [NB100-91723] - Extracts from 293 cells.
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NB100-91723] - Analyzes of CSE1L (E2) pAb in paraffin-embedded human breast carcinoma tissue at 1:100

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-91723
    • Availability
      Product Discontinued

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CSE1L/CAS/Exportin-2 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids N-terminus of Human CSE1L.
Clonality
Polyclonal
Host
Rabbit
Gene
CSE1L
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Immunoprecipitation 1:50-1:200
Theoretical MW
110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NB100-91723 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CSE1L/CAS/Exportin-2 Antibody

  • CAS
  • CASMGC117283
  • Cellular apoptosis susceptibility protein
  • chromosome segregation 1 (yeast homolog)-like
  • Chromosome segregation 1-like protein
  • CSE1 chromosome segregation 1-like (yeast)
  • CSE1
  • CSE1L
  • exp2
  • exportin-2
  • Importin-alpha re-exporter
  • MGC130037
  • XPO2
  • XPO2MGC130036

Background

Normal tissues are characterized by a balance between cellular stasis, cell proliferation, cell differentiation and cell death. Aberrant regulation of any of these cell processes can result in cancer. Cell death during embryogenesis, tissue atrophy and normal tissue turnover is called apoptosis. This is characterized by cytoplasmic and nuclear condensation, nuclear disorganization and fragmentation of genomic DNA into 180-200 base pair oligomers. Several human cDNA fragments have been shown to render MCF-7 cells resistant to cell death induced by Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diptheria toxin and tumor necrosis factor (TNF). One such fragment has proven to be the human homolog to the yeast chromosome segregation homolog, CSE1. Cloning of the full-length human cDNA has revealed a putative protein designated CAS, for cellular apoptosis susceptibility, that is 971 amino acids in length with 59% overall sequence homology as compared to yeast CSE1. CAS is highly expressed in testis and fetal liver. CAS expression in human fibroblasts increases as cells are induced to proliferate and decreases in growth arrested cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CSE1L/CAS/Exportin-2 Antibody (NB100-91723)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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Bioinformatics

Gene Symbol CSE1L
Entrez
Uniprot