CRTH-2/GPR44 Antibody


Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody [NLS3529] - Analysis of anti-GPR44 / CRTH2 antibody with human tonsil.

Product Details

Reactivity Hu, Mk, Canine, Equine, Primate, PorcineSpecies Glossary
Applications IHC-P
1.0 mg/ml

Order Details

CRTH-2/GPR44 Antibody Summary

A 34 amino acid synthetic peptide within the 2nd extracellular domain of human GPR44/CRTH2.
Plasma membrane; multi pass membrane protein.
Human GPR44 / CRTH2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Porcine (94%), Canine (94%), Primate (97%), Equine (91%). Backed by our 100% Guarantee.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS and 2% Sucrose
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


  • Immunohistochemistry-Paraffin 2.5 - 5 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Gorilla (97%), Panda (94%), Elephant (88%), Bovine (88%), Rabbit (85%), Mouse (82%), Hamster (82%).

Alternate Names for CRTH-2/GPR44 Antibody

  • CD294 antigen
  • CD294
  • Chemoattractant receptor-homologous molecule expressed on Th2 cells
  • CRTH2
  • CRTH2chemoattractant receptor homologous molecule expressed on T helper type 2 cells
  • DL1R
  • DP2
  • G protein-coupled receptor 44
  • GPR44
  • PGD2R
  • PTGDR2
  • putative G-protein coupled receptor 44


GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through GPR44 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. GPR44 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells. GPR44 has been reported to be expressed in the central nervous system, peripheral tissues, and in blood cells, particularly activated T helper-2 cells. Two transcripts have been isolated, a 3.5-kb transcript expressed primarily in the thalamus, frontal cortex, pons, and hippocampus, and a 3.4-kb transcript expressed in fetal liver, leukocytes, and thymus. ESTs have been isolated from B-cell/lung/testis, brain, kidney, liver/spleen, placenta, prostate, testis, and thymus libraries.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol PTGDR2

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