CRTH-2/GPR44 Antibody

Images

 
Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody [NLS3528] - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody [NLS3528] - Analysis of anti-GPR44 / CRTH2 antibody with transfected cells expressing GPR44 at 3 ug/ml.
Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody [NLS3528] - Analysis of anti-GPR44 / CRTH2 antibody with cells expressing vector only at 3 ug/ ml.
Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody [NLS3528] - Analysis of anti-GPR44 / CRTH2 antibody with nasal mucosa, eosinophils at 3 ug/ ml.
Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody [NLS3528] - Analysis of anti-GPR44 / CRTH2 antibody with human lymph node, non-Hodgkins lymphoma.

Product Details

Summary
Reactivity Hu, Mk, PmSpecies Glossary
Applications IHC-P, ICC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CRTH-2/GPR44 Antibody Summary

Immunogen
Synthetic 33 amino acid peptide from N-terminal extracellular domain of human GPR44 / CRTH2.
Localization
Plasma membrane; multi pass membrane protein.
Specificity
Human GPR44 / CRTH2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Monkey (91%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTGDR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 3-14 ug/ml
  • Immunocytochemistry 1:10 - 1:500
Positive Control
CRTH-2/GPR44 Lysate (NBL1-11281)

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Canine (88%), Porcine (88%), Rabbit (85%), Bovine (82%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CRTH-2/GPR44 Antibody

  • CD294 antigen
  • CD294
  • Chemoattractant receptor-homologous molecule expressed on Th2 cells
  • CRTH2
  • CRTH-2
  • CRTH2chemoattractant receptor homologous molecule expressed on T helper type 2 cells
  • DL1R
  • DP2
  • G protein-coupled receptor 44
  • GPR44
  • PGD2R
  • PTGDR2
  • putative G-protein coupled receptor 44

Background

GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells. CRTH2 has been reported to be expressed in the central nervous system, peripheral tissues, and in blood cells, particularly activated T helper-2 cells. Two transcripts have been isolated, a 3.5-kb transcript expressed primarily in the thalamus, frontal cortex, pons, and hippocampus, and a 3.4-kb transcript expressed in fetal liver, leukocytes, and thymus. ESTs have been isolated from B-cell/lung/testis, brain, kidney, liver/spleen, placenta, prostate, testis, and thymus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PTGDR2
Entrez