CRHR2/CRF2 Antibody

Images

 
Immunohistochemistry-Paraffin: CRHR2/CRF2 Antibody [NLS505] - Analysis of anti-CRHR2 / CRF2 Receptor antibody with human brain, glioblastoma.
Immunohistochemistry-Paraffin: CRHR2/CRF2 Antibody [NLS505] - Analysis of anti-CRHR2 / CRF2 Receptor antibody with brain, pituitary.

Product Details

Summary
Reactivity Hu, Rt, Eq, Mk, Pm, Mu, Po, Bv, Ca, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CRHR2/CRF2 Antibody Summary

Immunogen
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human CRHR2.
Specificity
Human CRHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CRHR1 (40%).
Predicted Species
Mouse (95%), Porcine (90%), Bovine (95%), Rabbit (95%), Canine (90%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CRHR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 6 ug/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (85%), Bat (85%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CRHR2/CRF2 Antibody

  • corticotropin releasing hormone receptor 2
  • corticotropin-releasing factor receptor 2
  • Corticotropin-releasing hormone receptor 2
  • CRF2
  • CRF2R
  • CRFR2
  • CRF-R2
  • CRF-R-2
  • CRFR-2
  • CRF-RB
  • CRH2R
  • CRHR2
  • CRH-R2
  • CRH-R-2
  • HM-CRF

Background

CRHR2, a Corticotropin-Releasing Factor Receptor is a neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Mutations of the receptor reduce coping behaviors to stress and increase basal blood pressure. Three isoforms of CRHR2 are produced by alternative splicing. CRHR2 expression has been reported in various regions of the brain, as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal, and skeletal muscle. CRCH2alpha is the dominant isoform and is expressed widely. CRCH2beta is expressed in the hippocampus, septum, amygdala, heart, and skeletal muscle. CRHR2gamma is brain-specific. ESTs have been isolated from brain libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CRHR2
Entrez