CPI17 alpha [p Thr38] Antibody

Images

 
Western Blot: CPI17 alpha Antibody [NBP1-51465] - Analysis of p-CPI-7 (T38) pAb in extracts from RAW264.7 cells.
Immunohistochemistry-Paraffin: CPI17 alpha Antibody [NBP1-51465] - Human heart tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51465
    • Availability
      Product Discontinued

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CPI17 alpha [p Thr38] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human CPI-17 around the phosphorylation site of Threonine 38.
Modification
p Thr38
Specificity
p-CPI-17 (T38) pAb detects endogenous levels of CPI-17 pAb protein only when phosphorylated at T38.
Clonality
Polyclonal
Host
Rabbit
Gene
PPP1R14A
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of p-CPI-17 (T38) pAb in extracts from RAW264.7 cells.
Immunohistochemistry (IHC) analyzes of p-CPI-17 (T38) pAb in paraffin-embedded human heart tissue.
Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CPI17 alpha [p Thr38] Antibody

  • 17 kDa PKC-potentiated inhibitory protein of PP1
  • CPI-1717-kDa PKC-potentiated inhibitory protein of PP1
  • CPI1717-KDa protein
  • PKC-potentiated inhibitory protein of PP1
  • PPP1INL
  • Protein kinase C-potentiated inhibitor protein of 17 kDa
  • protein phosphatase 1 regulatory subunit 14A
  • protein phosphatase 1, regulatory (inhibitor) subunit 14A

Background

CPI-17 is a phosphorylation-dependent inhibitory protein for smooth muscle Myosin phosphate. CPI-17 was originally identified as a 17 kDa PKC-potentiated inhibitory protein of protein phosphatase-1, which is dominantly expressed in smooth muscle. Phosphorylation at Threonin 38, in vitro, by PKC or Rho-kinase enhances the inhibitory potency toward myosin phosphatase. CPI-17 is also phosphorylated at Threonine 38 by protein kinase N and might be involved in the calcium sensitization of smooth muscle cont-raction as a downstream effector of Rho and/or arachidonic acid. CPI-17 is dually phosphorylated at Serine 12 and Threonine 38 by a MYPT-associated kinase, M110 kinase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PPP1R14A