COX-2 Antibody (5E10/D10)

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA
Clone
5E10/D10
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.9 mg/ml

Order Details

COX-2 Antibody (5E10/D10) Summary

Immunogen
A preparation of intracellular proteins of the human cell line HL60.
Localization
Membrane associated. Microsomal membrane.
Specificity
COX-2. No cross-reactivity with Cox-1.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
PTGS2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1.0-0.5 ug/ml
  • ELISA 0.5-0.1 ug/ml

Reactivity Notes

Cross-reacts with Human and Mouse.Not yet tested in other species. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (FCS free)
Preservative
0.02% Sodium Azide
Concentration
1.9 mg/ml
Purity
Protein A or G purified

Alternate Names for COX-2 Antibody (5E10/D10)

  • COX2
  • COX-2
  • COX2cyclooxygenase 2b
  • cyclooxygenase-2
  • EC 1.14.99
  • EC 1.14.99.1
  • GRIPGHS
  • hCox-2
  • PGG/HS
  • PGH synthase 2
  • PGHS-2
  • PHS II
  • PHS-2
  • PHS-II
  • prostaglandin G/H synthase 2
  • prostaglandin G/H synthase and cyclooxygenase
  • Prostaglandin H2 synthase 2
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase andcyclooxygenase)
  • Prostaglandin-endoperoxide synthase 2
  • PTGS2

Background

COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics Tool for COX-2 Antibody (NB600-997)

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Bioinformatics

Gene Symbol PTGS2
Entrez