Cortisol Antibody (C13 (BGN/C13))

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Product Details

Summary
Product Discontinued
View other related Cortisol Primary Antibodies

Order Details


    • Catalog Number
      NB100-62485
    • Availability
      Product Discontinued

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Cortisol Antibody (C13 (BGN/C13)) Summary

Immunogen
Cortisol conjugated to bovine serum albumin
Specificity
This product recognizes cortisol, a glucocorticoid hormone synthesized from cholesterol by the adrenal cortex. It is released in response to pituitary adenocorticotrophic hormone (ACTH) which is, in turn, regulated by corticotrophin releasing factor (CRF). High levels of cortisol act to regulate the release of ACTH and CRF via negative feedback inhibition. The release of cortisol stimulates the conversion of proteins to carbohydrates, raises blood sugar levels and promotes glycogen storage in the liver. The following cross reactivities were observed: Cortisol 100% Prednisolone 30% Cortisone 25% Corticosterone 10% 11-desoxycortisol 5%. No reactivity was observed with 17-a-OH-progesterone.
Isotype
IgG3
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000

Reactivity Notes

All Species. Expected to react with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Cortisol Antibody (C13 (BGN/C13))

  • Compound F
  • Cortisol
  • Hydrocortisone

Background

Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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