Recombinant Mouse Common beta Chain Protein

Images

 
SDS-Page: IL3RB Protein [NBC1-18483] - mGM-CSF, 14 kDa (125 aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Func, PAGE
Concentration
1 mg/ml

Order Details

Recombinant Mouse Common beta Chain Protein Summary

Description
An un-tagged recombinant protein corresponding to the amino acids 18-141 of Mouse Common beta Chain

Source: E.coli

Amino Acid Sequence: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK

Details of Functionality
Measured in a cell proliferation assay using MC/9 cells. The ED50 for this effect is less or equal to 0.5 ng/ml.
Source
E. coli
Protein/Peptide Type
Biologically Active Protein
Gene
CSF2RB
Purity
>95% pure by SDS-PAGE
Endotoxin Note
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Applications/Dilutions

Theoretical MW
14 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline (pH 7.4), 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Mouse Common beta Chain Protein

  • beta, low-affinity
  • CD131 antigen
  • CD131
  • CDw131
  • colony stimulating factor 2 receptor, beta, low-affinity(granulocyte-macrophage)
  • Common beta Chain
  • CSF2RB
  • cytokine receptor common subunit beta
  • GM-CSF R beta
  • GM-CSF/IL-3/IL-5 receptor common beta subunit
  • GM-CSF/IL-3/IL-5 receptor common beta-chain
  • IL-3 R beta
  • IL3RB
  • IL-5 R beta
  • interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3receptor, beta (high affinity)

Background

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. Mouse GM-CSF protein is 125 amino acids and shares approximately 60% homology with the human GM-CSF protein. Recombinant mouse GM-CSF was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

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Bioinformatics

Gene Symbol CSF2RB
Entrez