Collagen III alpha 1/COL3A1 Antibody (MC3-HA)

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Order Details


    • Catalog Number
      NBP1-42215
    • Availability
      Product Discontinued

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Collagen III alpha 1/COL3A1 Antibody (MC3-HA) Summary

Immunogen
The antibody reacts with the Collagen III antigen.
Specificity
This monoclonal antibody reacts exclusively with human colla­gen type III in RIA, ELISA and dot blot. It lacks cross reactivity with any other collagen type and plasma proteins.
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Gene
COL3A1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
The antibody can be used for staining of collagen III in frozen sections. Furthermore it is useful for detection of collagen III by ELISA, RIA and immunoblotting.For immunohistochemistry on frozen sections fixation with acetone for 5 min. at -20C is recommended. Staining of paraffin material generally renders less successful results. Working dilution: 1:20. Optimal dilution should be tested by serial dilutions.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Ascites
Preservative
No Preservative
Purity
Unpurified

Alternate Names for Collagen III alpha 1/COL3A1 Antibody (MC3-HA)

  • alpha1 (III) collagen
  • COL3A1
  • Collagen 3
  • collagen alpha-1(III) chain
  • Collagen III alpha 1
  • collagen, fetal
  • collagen, type III, alpha 1
  • Collagen-3
  • EDS4A
  • Ehlers-Danlos syndrome type IV, autosomal dominant
  • FLJ34534

Background

These antibodies are well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol COL3A1
Entrez