Cofilin [p Ser3] Antibody


Western Blot: Cofilin [p Ser3] Antibody [NBP1-51420] - Extracts from 3T3 paclitaxel cells.
Immunohistochemistry-Paraffin: Cofilin [p Ser3] Antibody [NBP1-51420] - Paraffin-embedded human breast carcinoma tissue at 1:100.
Immunohistochemistry-Paraffin: Cofilin [p Ser3] Antibody [NBP1-51420] - Human lung carcinoma tissue.

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Cofilin [p Ser3] Antibody Summary

Synthetic phosphopeptide derived from human Cofilin 1 around the phosphorylation site of Serine 3.
p Ser3
p-Cofilin (S3) pAb detects endogenous levels of Cofilin protein only when phosphorylated at S3.
Immunogen affinity purified
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  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analyzes of p-Cofilin (S3) pAb in extracts from 3T3 paclitaxel cells.
Immunohistochemistry (IHC) analyzes of p-Cofilin (S3) pAb in paraffin-embedded human lung carcinoma tissue.
Theoretical MW
19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for Cofilin [p Ser3] Antibody

  • 18 kDa phosphoprotein
  • CFL
  • cofilin 1 (non-muscle)
  • Cofilin, non-muscle isoform
  • cofilin-1
  • p18


LIM-kinase 1 (LIMK-1) is a serine/threonine kinase containing LIM and PDZ domains. LIMK-1 phosphorylates Cofilin on Ser 3 both in vitro and in vivo. Cofilin is an Actin-depolymerizing factor and regulates Actin cytoskeletal reorganization. Phosphorylation of Cofilin on Ser 3 is known to block these activities. Phosphorylation of ADF/Cofilin proteins by LIMK-1 or other enzymes will tend to stabilize Actin filaments by inhibiting the ability of these proteins to sever and depolymerize older Actin filaments that have hydrolyzed their bound ATP and dissociated the phosphate. The rapid turnover of Actin filaments and the tertiary meshwork formation are regulated by a variety of Actin-binding proteins. Cofilin, therefore, is a terminal effector of signaling cascades that evokes Actin cytoskeletal rearrangement.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol CFL1