COCO/DAND5 Antibody (3A3)

Images

 
Immunocytochemistry/ Immunofluorescence: DAND5 Antibody (3A3) [NBP2-01339] Staining of COS7 cells transiently transfected by pCMV6-ENTRY DAND5.
Flow Cytometry: DAND5 Antibody (3A3) [NBP2-01339] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DAND5 antibody, and then analyzed ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-01339
    • Availability
      Product Discontinued

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COCO/DAND5 Antibody (3A3) Summary

Immunogen
Human recombinant protein fragment corresponding to amino acids 23-189 of human DAND5(NP_689867) produced in E.coli.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
DAND5
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:100
  • Immunocytochemistry/Immunofluorescence 1:100

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for COCO/DAND5 Antibody (3A3)

  • CER2CRL2
  • Cerberus 2
  • Cerberus like-2
  • cerberus-like 2
  • Cerberus-like protein 2
  • CERL2
  • cerl-2
  • CKTSF1B3
  • CKTSF1B3MGC126849
  • COCO
  • Cysteine knot superfamily 1, BMP antagonist 3
  • DAN domain family member 5
  • DAN domain family, member 5
  • DAND5
  • Dante
  • DTE
  • FLJ38607
  • GREM3
  • GREM3cerberus 2
  • gremlin-3
  • SP1

Background

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol DAND5
Entrez