Biological Strategies: Western Blot: cleaved BAD Antibody [NB100-56602] - Western blot analysis of Bad-cv using NB100-56602 at 1:500 against lysate of (A) untreated HeLa cells and (B) HeLa cells treated with TNFa ...read more
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS with 0.1 mg/ml BSA
0.05% Sodium Azide
Protein G purified
Alternate Names for cleaved BAD Antibody
bcl2 antagonist of cell death
BCL2-antagonist of cell death protein
BCL2-associated agonist of cell death
Bcl-2-binding component 6
BCL2-binding component 6
Bcl-2-like protein 8
BCL-X/BCL-2 binding protein
Bcl-XL/Bcl-2-associated death promoter
The function of Bad, a proapoptotic member of the Bcl-2 family, is regulated primarily by rapid changes in phosphorylation that modulate its protein-protein interactions and subcellular localization. Human Bad, which is 43 amino acids shorter than its mouse counterpart, is cleaved by a caspase upon exposure of Jurkat T cells to anti-FAS antibody, tumor necrosis factor alpha (TNF-alpha), or TRAIL. Moreover, a truncated form of human Bad lacking the N-terminal 28 amino acids is more potent than wild-type Bad in inducing apoptosis. Bad plays a novel and important role in maintaining the apoptotic phenotype in response to various apoptosis inducers.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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