Claudin-1 Antibody

Images

 
Western Blot: Claudin-1 Antibody [NBP1-35652] - Hela
Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP1-35652] - Human Skin

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Claudin-1 Antibody Summary

Immunogen
Synthetic peptide derived from C-terminus of human Claudin-1 peptide.
Localization
Cell Junction, Cytoplasm, Membrane
Specificity
This product is specific for Claudin 1
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CLDN1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:200

Reactivity Notes

Human and Mouse. Predicted cross-reactivity based on sequence identity: Bovine, Dog, Pig, Rat.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.6) and 1.0% BSA
Preservative
Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Claudin-1 Antibody

  • claudin 1
  • Claudin1
  • Claudin-1
  • CLD1
  • CLDN1
  • ILVASCSenescence-associated epithelial membrane protein
  • SEMP1
  • SEMP1senescence-associated epithelial membrane protein 1

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Claudin-1 Antibody (NBP1-35652). (Showing 1 - 1 of 1 FAQ).

  1. We are looking for two corresponding products, claudin 1 antibody and a peptide which can blocks the CLDN1.Could you plase kindly provide us solution for it? We found at your website one product, namely Claudin 1 Peptide ( NBP1-77036PEP),which can be used for blocking the activity of CLDN1. For the immunogen, 20 amino acids near the carboxy terminus of CLDN1 was mentioned. We found four Claudin 1 antibody ( NBP1-74546,NBP1-35652,NBP1-74517,H00009076-M1),and the immunogen was again the C-terminus of the Claudin 1.Cold you please send me more information about this C-terminus sequence?Is it the same in case of the NBP1-77036PEP and the four mentined antibodies?
    • The blocking peptide is a good purchase. The epitope for NBP1-35652 has not been mapped and the immunogen sequence is confidential, it is contained within the range between aa 140-211 of O95832 (Uniprot). Unfortunately NBP1-74517 has been discontinued. The amino acid sequence for H00009076-M01 is (AAH12471.1, 1 a.a. ~ 211 a.a). Unfortunately the lab that provides NBP1-74546 will not provide me with an aa range for the epitope as this is proprietary information that they are not willing to pass on.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CLDN1
Entrez
Uniprot