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Chk1 Antibody (2G3)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      H00001111-M05
    • Availability
      Product Discontinued

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Chk1 Antibody (2G3) Summary

Description
Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen
CHEK1 (AAH04202 361 a.a. - 476 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKVWLPAT
Specificity
CHEK1 (2G3)
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CHEK1
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
Application Notes
Antibody reactivity against recombinant protein on ELISA. GST alone used as a negative control.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Chk1 Antibody (2G3)

  • Checkpoint, S. pombe, homolog of, 1
  • CHEK1
  • CHK1 (checkpoint, S.pombe) homolog
  • CHK1 checkpoint homolog (S. pombe)
  • Chk1
  • CHK1serine/threonine-protein kinase Chk1
  • EC 2.7.11
  • EC 2.7.11.1

Background

Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Chk1 Antibody (2G3)
H00001111-M05
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Bioinformatics

Gene Symbol CHEK1
Entrez
OMIM
Uniprot