CEACAM5/CD66e Antibody (CLB-139)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42483
    • Availability
      Product Discontinued

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CEACAM5/CD66e Antibody (CLB-139) Summary

Immunogen
human granulocytes.
Specificity
The monoclonal antibody is directed against the CD66e-antigen, a 180-200 kD phosphoprotein, 90 kD PI-linked protein, which is expressed on mature human granulocytes. After activation of the granulocutes, expression the antigen is strongly increased. It reacts with 100% of mature human peripheral granulo­cytes. The monoclonal antibody reacts weakly with malignant cells of patients with B-cell derived chronic lymphoid leukemia (CLL). The monoclonal antibody does not react with normal human peripheral B-cells, T-cells, monocytes and platelets. In immuno­histolo­gy the antibody reacts with a subpopulation of tissue macrophages and the Carcino Embry­onic Antigen (CEA) expressed on colon carcinoma and other carcinomas.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CEACAM5
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
Monitoring of mature granulocytes in peripheral blood.The antibody is useful for indirect immunofluorescence staining with analysis by flowcytometry or fluorescence microscopy.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
No Preservative
Purity
Protein A or G purified

Alternate Names for CEACAM5/CD66e Antibody (CLB-139)

  • Carcinoembryonic antigen
  • carcinoembryonic antigen-related cell adhesion molecule 5
  • CD66e antigen
  • CD66e
  • CEA
  • CEACAM5
  • CEACAM-5
  • CEACD66e
  • DKFZp781M2392
  • Meconium antigen 100

Background

Carcino Embryonic Antigen (CEA) is synthesized during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. Antibodies to CEA are useful in identifying the origin of various metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinomas (60 to 70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol CEACAM5
Entrez