Cdk6 Antibody

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Immunocytochemistry/ Immunofluorescence: Cdk6 Antibody [NBP1-04956] - CDK6(Ab-13) Antibody
Immunohistochemistry: CDK6 Antibody [NBP1-04956] - Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CDK6 (Ab-13) Antibody

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-04956
    • Availability
      Product Discontinued

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Cdk6 Antibody Summary

Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human CDK6 around the phosphorylation site of tyrosine 13 (Q-Q-Yp-E-C).
Specificity
CDK6 (Ab-13) detects endogenous levels of total CDK6 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
CDK6
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:100

Reactivity Notes

This antibody is cross-reactive against Human, Mouse

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol.
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cdk6 Antibody

  • Cell division protein kinase 6
  • cyclin-dependent kinase 6
  • EC 2.7.11
  • EC 2.7.11.22
  • PLSTIREMGC59692
  • Serine/threonine-protein kinase PLSTIRE

Background

Cdk6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of Cdk6 first appears in mid-G1 phase, and is controlled by regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CDK6
Entrez
Uniprot